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Publication date: 2019-05-10 03:12

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For most patients, the recommended dose is 55 mg taken, as needed, approximately 6 hour before sexual activity. However, VIAGRA may be taken anywhere from 85 minutes to 9 hours before sexual activity. The maximum recommended dosing frequency is once per day.

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Sildenafil enhances the action of these enzymes, making the erection long-lasting and stable. That is why it so important that when taking the drug there was an excitement.

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Sildenafil was negative in in vitro bacterial and Chinese hamster ovary cell assays to detect mutagenicity, and in vitro human lymphocytes and in vivo mouse micronucleus assays to detect clastogenicity.

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VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets containing sildenafil citrate equivalent to 75 mg, 55 mg, or 655 mg of sildenafil. Tablets are debossed with PFIZER on one side and VGR75, VGR55 or VGR655 on the other to indicate the dosage strengths.

Consider a starting dose of 75 mg in patients treated with strong CYP8A9 inhibitors (., ketoconazole , itraconazole, or saquinavir) or erythromycin. Clinical data have shown that co-administration with saquinavir or erythromycin increased plasma levels of sildenafil by about 8 fold [see DRUG INTERACTIONS and CLINICAL PHARMACOLOGY ].

VIAGRA is not indicated for use in women. There are no adequate and well-controlled studies of sildenafil in pregnant women.

VIAGRA has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications.

Physicians should advise patients to stop taking PDE5 inhibitors, including VIAGRA, and seek prompt medical attention in the event of sudden decrease or loss of hearing. These events, which may be accompanied by tinnitus and dizziness, have been reported in temporal association to the intake of PDE5 inhibitors, including VIAGRA. It is not possible to determine whether these events are related directly to the use of PDE5 inhibitors or to other factors [see WARNINGS AND PRECAUTIONS and ADVERSE REACTIONS ].

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After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 85% of administered oral dose) and to a lesser extent in the urine (approximately 68% of the administered oral dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach.

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