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Viagra (Sildenafil Citrate): Side Effects, Interactions

Publication date: 2018-04-19 20:10

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Use caution when co-administering alpha-blockers with VIAGRA because of potential additive blood pressure-lowering effects. When VIAGRA is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment and VIAGRA should be initiated at the lowest dose [see DOSAGE AND ADMINISTRATION , WARNINGS AND PRECAUTIONS , CLINICAL PHARMACOLOGY ].


After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 85% of administered oral dose) and to a lesser extent in the urine (approximately 68% of the administered oral dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach.

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Across all trials, VIAGRA improved the erections of 98% of radical prostatectomy patients compared to 65% on placebo.

The co-administration of vardenafil with nitrates or nitric oxide donors (such as amyl nitrite) in any form is contraindicated (see sections and ).

The total body clearance of vardenafil is 56 l/h with a resultant terminal half-life of approximately 9-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the faeces (approximately 96-95% of the administered dose) and to a lesser extent in the urine (approximately 7-6% of the administered dose).

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Viagra (Sildenafil Citrate): Side Effects, Interactions Levitra dosage maximum

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