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Viagra (Sildenafil Citrate): Side Effects, Interactions

Publication date: 2018-06-08 02:34

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In a double-blind study, 699 patients with erectile dysfunction and chronic stable angina limited by exercise, not receiving chronic oral nitrates, were randomized to a single dose of placebo or VIAGRA 655 mg 6 hour prior to exercise testing. The primary endpoint was time to limiting angina in the evaluable cohort. The mean times (adjusted for baseline) to onset of limiting angina were and seconds for sildenafil (N=75) and placebo, respectively. These results demonstrated that the effect of VIAGRA on the primary endpoint was statistically non-inferior to placebo.

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Therefore, age 65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 75 mg should be considered in those patients [see DOSAGE AND ADMINISTRATION ].

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Sildenafil citrate is a white to off-white crystalline powder with a solubility of mg/mL in water and a molecular weight of .

When Viagra was taken as recommended (on an as-needed basis) in flexible-dose, placebo-controlled clinical trials of two to twenty-six weeks duration, patients took Viagra at least once weekly, and the following adverse reactions were reported:

The recommended dose for ritonavir-treated patients is 75 mg prior to sexual activity and the recommended maximum dose is 75 mg within a 98 hour period because concomitant administration increased the blood levels of sildenafil by 66-fold [see WARNINGS AND PRECAUTIONS , DRUG INTERACTIONS , and CLINICAL PHARMACOLOGY ].

Nervous: ataxia, hypertonia, neuralgia, neuropathy, paresthesia, tremor, vertigo, depression, insomnia, somnolence, abnormal dreams, reflexes decreased, hypesthesia.

Digestive: vomiting, glossitis , colitis , dysphagia , gastritis , gastroenteritis , esophagitis , stomatitis, dry mouth, liver function tests abnormal, rectal hemorrhage, gingivitis.

Prolonged erection greater than 9 hours and priapism (painful erections greater than 6 hours in duration) have been reported infrequently since market approval of VIAGRA. In the event of an erection that persists longer than 9 hours, the patient should seek immediate medical assistance. If priapism is not treated immediately, penile tissue damage and permanent loss of potency could result.

If you’ve tried VIAGRA and if you're still not getting results, ask your doctor to see if adjusting your dose might help. Remember, VIAGRA should not be taken more than one time a day.

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